The new Comiskey Park opened on April 18, 1991, making the White Sox the first team to open a new ballpark in the 1990s.  The Illinois General Assembly passed legislation in 1987 to have the Illinois Sports Facilities Authority, the current developer, owner and operator, to construct the park directly across the street from old Comiskey Park.  On May 7, 1989, a groundbreaking ceremony was held with Mayor Richard M. Daley and Governor James R. Thompson in attendance.  On April 18, 1991, the new ballpark officially opened, with Governor Thompson throwing out the ceremonial first pitch.  The new ballpark featured an exploding scoreboard, an old-time facade complete with arches and more than 40,000 unobstructed-view seats.  In 2003, it was renamed U.S. Cellular Field.

Charles Comiskey built White Sox Park on the corner of 35th Street and Shields Avenue. Opening on July 1, 1910, it soon became known as Comiskey Park.  On August 14, 1939, the first night game in the City of Chicago was played at Comiskey Park, with the Sox defeating the St. Louis Browns by a score of 5-2.

The first home of the Chicago White Sox was located at 39th Street and Princeton. The 39th Street Grounds served as the playing field of the Chicago Wanderers cricket team during the 1893 World's Fair. Charles Comiskey built a wooden grandstand on the site in 1900, serving as the home of the White Sox for up to 7,500 fans, until June 27, 1910 when the club vacated the park for White Sox Park.